In 2049, replicants (bioengineered humans) have been integrated into society as servants and slaves. K, one of these integrated replicants, works for the LAPD as a „Blade Runner”—an agent who hunts down and „retires” (eliminates) rogue replicants. He lives with his holographic girlfriend Joi, an artificial intelligence product of the replicant manufacturer Wallace Corporation.
After K retires the rogue replicant Sapper Morton, he finds a box buried on Morton’s farm containing bones; forensic analysis reveals they are the remains of a female replicant who died during an emergency caesarean section, contradicting the belief that replicants are sterile. Fearful that this knowledge could lead to a human-replicant war, K’s superior, Lieutenant Joshi, orders K to destroy the evidence and retire the replicant child.
K visits the Wallace Corporation headquarters, where the deceased female is identified from DNA archives as Rachael, an experimental replicant designed by Dr. Tyrell. K learns of Rachael’s romantic ties with former blade runner Rick Deckard. The CEO, Niander Wallace, wants to discover the secret to replicant reproduction to expand interstellar colonization, and sends his replicant enforcer Luv to steal Rachael’s remains from LAPD headquarters and follow K to Rachael’s child.